In the federal numbering system, odd numbers go with north-south highways, although brief segments may run east-west. The lowest numbers are assigned to the east coast.
- U.S. 101, Oregon Coast Highway, Redwood Highway, El Camino Real, Olympia, WA to Los Angeles
- U.S. 99, Golden State Highway, Canadian border (Blaine, WA) to Calexico, CA
- Canadian border to Mexican border U.S. 95
- U.S. 93
- U.S. 89 National Park Highway
- Havre, MT to Pt. Lavaca, TX U.S. 87
- U.S. 85 CanAm Highway
- Terminates at both borders, continuing as MB Highway 83 and as Mexican Federal Highway 180. U.S. 83
- Canadian border (Pembina, ND) to Ft. Worth, TX at I-35W U.S. 81
- Sioux City, IA at I-29 to Mexican border at Brownsville. U.S. 77
- Canadian border to I-30/45, Dallas, TX U.S. 75
- International Falls, MN to US-190 (LA) U.S. 71
- U.S. 67
- U.S. 65
- U.S. 63
- U.S. 61 Local names: Avenue of the Americas, Airline Highway
- U.S. 51
- U.S. 45
- U.S. 41 Route of the Blue and Gray
- Michigan City (IN) to Scott Depot (WV) U.S. 35
- Lincoln Way: Ft. Wayne to Elkhart, IN U.S. 33 Lincoln Highway (IN)
- U.S. 31
- U.S. 27
- U.S. 25 Dixie Highway
- Mackinaw City, MI to Jacksonville, FL U.S. 23
- U.S. 19 Dixie Highway
- U.S. 17
- U.S. 13
- U.S. 11
- U.S. 1: Atlantic Highway, Overseas Highway