In the federal numbering system, odd numbers go with north-south highways, although brief segments may run east-west. The lowest numbers are assigned to the east coast.
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- U.S. 101, Oregon Coast Highway, Redwood Highway, El Camino Real, Olympia, WA to Los Angeles
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- U.S. 99, Golden State Highway, Canadian border (Blaine, WA) to Calexico, CA
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- Canadian border to Mexican border U.S. 95
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- U.S. 93
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- U.S. 89 National Park Highway
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- Havre, MT to Pt. Lavaca, TX U.S. 87
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- U.S. 85 CanAm Highway
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- Terminates at both borders, continuing as MB Highway 83 and as Mexican Federal Highway 180. U.S. 83
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- Canadian border (Pembina, ND) to Ft. Worth, TX at I-35W U.S. 81
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- Sioux City, IA at I-29 to Mexican border at Brownsville. U.S. 77
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- Canadian border to I-30/45, Dallas, TX U.S. 75
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- International Falls, MN to US-190 (LA) U.S. 71
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- U.S. 67
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- U.S. 65
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- U.S. 63
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- U.S. 61 Local names: Avenue of the Americas, Airline Highway
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- U.S. 51
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- U.S. 45
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- U.S. 41 Route of the Blue and Gray
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- Michigan City (IN) to Scott Depot (WV) U.S. 35
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- Lincoln Way: Ft. Wayne to Elkhart, IN U.S. 33 Lincoln Highway (IN)
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- U.S. 31
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- U.S. 27
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- U.S. 25 Dixie Highway
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- Mackinaw City, MI to Jacksonville, FL U.S. 23
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- U.S. 19 Dixie Highway
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- U.S. 17
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- U.S. 13
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- U.S. 11
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- U.S. 1: Atlantic Highway, Overseas Highway