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U.S. 2, Theodore Roosevelt Highway, America’s northernmost federal highway
U.S. 6, Grand Army of the Republic Highway , aka. King’s Highway Roosevelt Highway Midland Trail White Pole Road (IA)
U.S. 8
U.S. 10, Part of U.S. 10 includes a ferry route across Lake Michigan (Parts of the Yellowstone Trail were routed on this highway)
U.S. 12, Dunes Highway in MI and IN (Parts of the Yellowstone Trail were routed on this highway)
U.S. 14, Northwest Highway in IL (Parts of the Yellowstone Trail were routed on this highway)
U.S. 16 (Parts of the Yellowstone Trail were routed on this highway)
U.S. 20, U.S. Grant Highway
U.S. 24, Midland Trail
U.S. 26
U.S. 30, Lincoln Highway
U.S. 34, Ogden Avenue Red Bull Highway (IA), Berwyn, IL to Granby, CO
Currently: Uhrichsville, OH to Rocky Mt. Nat’l Park, CO, U.S. 36
National Road (E) Victory Highway (W), U.S. 40
U.S. 50
U.S. 52, Charleston, SC to Portal, ND
Mid-America’s Diagonal Boulevard, U.S. 54
U.S. 60
Niagara Falls to El Paso, U.S. 62, Ozark Trail, The only even numbered route from border to border
US 158 to US 160, U.S. 64
U.S. 66, The Mother Road Main Street of America
U.S. 70, U.S. Grant Highway
U.S. 80
U.S. 82
U.S. 84, I-95 to U.S. 160
U.S. 90, Skims the Southern U.S. border, Atlantic Coast to Van Horn, TX